8/22/2023 0 Comments Single cell sequence![]() ![]() Paralleling the wide diversity of their interactions, astrocytes have been reported to play key roles in supporting CNS structure, metabolism, blood–brain barrier formation, and control of vascular blood flow, axon guidance, synapse formation, and modulation of synaptic transmission 1. They possess thousands of individual processes, which extend out into the neuropil, interacting with neurons, other glia, and blood vessels. The data are available through an online database ( ), providing a resource on which to base explorations of local astrocyte diversity and function in the brain.Īstrocytes are ubiquitous in the central nervous system (CNS). Our findings are evidence for specialized astrocyte subtypes between and within brain regions. Validation of our data in situ reveals distinct spatial positioning of defined subtypes, reflecting the distribution of morphologically and physiologically distinct astrocyte populations. Our analysis identifies five transcriptomically distinct astrocyte subtypes in adult mouse cortex and hippocampus. To investigate the true extent of astrocyte molecular diversity across forebrain regions, we used single-cell RNA sequencing. Crucially, emerging evidence shows specific adaptations and astrocyte-encoded functions in regions, such as the spinal cord and cerebellum. Astrocytes, a major cell type found throughout the central nervous system, have general roles in the modulation of synapse formation and synaptic transmission, blood–brain barrier formation, and regulation of blood flow, as well as metabolic support of other brain resident cells. ![]()
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